Para los NFKBologos

El papel de la ubiquitacion y proteolisis en NFkB
Nature Cell Biology 7, 758 - 765 (2005)
Ubiquitin signalling in the NF-B pathway
The transcription factor NF-B controls many processes, including immunity, inflammation and apoptosis. Ubiquitination regulates at least three steps in the NF-B pathway: degradation of IB (inhibitor of NF-B), processing of NF-B precursors, and activation of the IB kinase (IKK). Recent studies have revealed several enzymes involved in the ubiquitination and deubiquitination of signalling proteins that mediate IKK activation through a degradation-independent mechanism.

Ah! y felicidades a Juan Carlos por ser el primero en colocar un comentario.

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