One hallmark of cancer is intrinsic or acquired resistance
to apoptosis. Surprisingly, recent studies demonstrate that
CD95/Fas/Apo1 and p53 upregulated mediator of apoptosis/
PUMA (potent inducers of the death receptor and the
mitochondrial apoptotic pathways, respectively) promote
tumorigenesis. These findings provide important insights
into the multifaceted roles of apoptosis in tumorigenesis.
http://www.nature.com/onc/journal/v30/n16/pdf/onc2010573a.pdf
Tuesday, May 03, 2011
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