International network of cancer genome projects

Nature 464, 993-998 (15 April 2010) doi:10.1038/nature08987

International Cancer Genome Consortium
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The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.

Cancer remodeling in a basal-like breast cancer metastasis and xenograft.

Nature. April 15, 2010.

Genome remodelling in a basal-like breast cancer metastasis and xenograft

Massively parallel DNA sequencing allows entire genomes to be screened for genetic changes associated with tumour progression. Here, the genomes of four DNA samples from a 44-year-old African-American patient with basal-like breast cancer were analysed. The samples came from peripheral blood, the primary tumour, a brain metastasis and a xenograft derived from the primary tumour. The findings indicate that cells with a distinct subset of the primary tumour mutation might be selected during metastasis and xenografting.

http://www.nature.com/nature/journal/v464/n7291/abs/nature08987.html

doi:10.1038/nature08989