Cancer remodeling in a basal-like breast cancer metastasis and xenograft.

Nature. April 15, 2010.

Genome remodelling in a basal-like breast cancer metastasis and xenograft

Massively parallel DNA sequencing allows entire genomes to be screened for genetic changes associated with tumour progression. Here, the genomes of four DNA samples from a 44-year-old African-American patient with basal-like breast cancer were analysed. The samples came from peripheral blood, the primary tumour, a brain metastasis and a xenograft derived from the primary tumour. The findings indicate that cells with a distinct subset of the primary tumour mutation might be selected during metastasis and xenografting.

http://www.nature.com/nature/journal/v464/n7291/abs/nature08987.html

doi:10.1038/nature08989