BRIEF COMMUNICATION
Nature Methods 7, 447–449 (1 June 2010) | doi:10.1038/nmeth.1455
http://www.nature.com/news/2010/100509/full/news.2010.228.html
Coding of facial expressions of pain in the laboratory mouse
Dale J Langford , Andrea L Bailey , Mona Lisa Chanda , Sarah E Clarke , Tanya E Drummond , Stephanie Echols , Sarah Glick , Joelle Ingrao , Tammy Klassen-Ross , Michael L LaCroix-Fralish , Lynn Matsumiya , Robert E Sorge , Susana G Sotocinal , John M Tabaka , David Wong , Arn M J M van den Maagdenberg , Michel D Ferrari , Kenneth D Craig & Jeffrey S Mogil
Abstract
Facial expression is widely used as a measure of pain in infants; whether nonhuman animals display such pain expressions has never been systematically assessed. We developed the mouse grimace scale (MGS), a standardized behavioral coding system with high accuracy and reliability; assays involving noxious stimuli of moderate duration are accompanied by facial expressions of pain.
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