Cada vez se encuentran mas datos de la participacion del resto de la economia de nuestro organismo en la iniciacion y progresion del cancer.
New work with human breast cancer cells shows that they cooperate with mesenchymal stem cells (MSCs) derived from the bone marrow to advance metastasis. The breast cancer cells prompt MSCs to produce a cytokine, CCL5, that acts on cancer cells to promote their invasion and metastasis. Significantly, the MSC-stimulated cancer cells do not acquire a stable metastatic phenotype; rather they revert to their pre-malignant state in the absence of contextual signals. This raises the possibility that metastatic programming of cancer cells may be reversed therapeutically by targeting CCL5 or its receptor.
Article: Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
doi:10.1038/nature06188 4 October 2007
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