Revision de checkpoint mitotico

Minireview

Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death
Beth A.A. Weaver¹ and Don W. Cleveland
Cancer Cell, Vol 8, 7-12, July 2005
Disrupted passage through mitosis often leads to chromosome missegregation and the production of aneuploid progeny. Aneuploidy has long been recognized as a frequent characteristic of cancer cells and a possible cause of tumorigenesis. Drugs that target mitotic spindle assembly are frequently used to treat various types of human tumors. These lead to chronic mitotic arrest from sustained activation of the mitotic checkpoint. Here, we review the linkage between the mitotic checkpoint, aneuploidy, adaptation from mitotic arrest, and antimitotic drug-induced cell death.
Importante para revisar, sobre todo ruben, por lo de la crisis mitotica

LINK A ARTICULO COMPLETO VIA BIBLIOTECA BIOMEDICAS