One hallmark of cancer is intrinsic or acquired resistance
to apoptosis. Surprisingly, recent studies demonstrate that
CD95/Fas/Apo1 and p53 upregulated mediator of apoptosis/
PUMA (potent inducers of the death receptor and the
mitochondrial apoptotic pathways, respectively) promote
tumorigenesis. These findings provide important insights
into the multifaceted roles of apoptosis in tumorigenesis.
http://www.nature.com/onc/journal/v30/n16/pdf/onc2010573a.pdf
Tuesday, May 03, 2011
Wednesday, April 20, 2011
EMT theory for metastases challenged during AACR
It can't be easy to stand in front of hundreds of colleagues and tell them that ten years of research has led them in the wrong direction. But at the annual meeting of the American Association for Cancer Research (AACR) earlier this month, pathologist David Tarin did just that, by challenging a leading hypothesis on how cancers metastasize...
PARA VER EL TEXTO COMPLETO GRATUITO
PARA VER EL TEXTO COMPLETO GRATUITO
Saturday, April 02, 2011
Academic bias & biotech failures
The unspoken rule is that at least 50% of the studies published even in top tier academic journals – Science, Nature, Cell, PNAS, etc… – can’t be repeated with the same conclusions by an industrial lab.
Artículo completo (libre acceso):
Artículo completo (libre acceso):
Monday, March 14, 2011
Whole genome sequencing of single tumor cells: A method to infer Tumor evolution? Nature 2011
Tumour evolution inferred by single-cell sequencing
Nature (2011) doi:10.1038/nature09807
Received 25 May 2010 Accepted 07 January 2011 Published online 13 March 2011
Nature (2011) doi:10.1038/nature09807
Received 25 May 2010 Accepted 07 January 2011 Published online 13 March 2011
Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-κB: implication in breast cancer metastasis.
Oncogene. 2011 Mar 7. [Epub ahead of print]
Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-κB: implication in breast cancer metastasis.
publication, 7 March 2011; doi:10.1038/onc.2011.28.
Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-κB: implication in breast cancer metastasis.
publication, 7 March 2011; doi:10.1038/onc.2011.28.
Friday, March 11, 2011
Breast cancer: Luminal cells with an identity crisis
Breast cancer: Luminal cells with an identity crisis
Gemma K. Alderton
Abstract
Inherited mutations in BRCA1 seem to specifically increase the risk of developing basal-like breast cancers; so, Proia and colleagues investigated how BRCA1 might promote the formation of this subtype of breast cancer.Using samples from reduction mammoplasty (BRCA1+/+) and prophylactic mastectomy from individuals with BRCA1 mutations (BRCA1mut/+), Proia and colleagues transformed cell suspensions with four tumorigenic genes (TP53R175H, CCND1, PI3KCA and KRASG12V) that are
Gemma K. Alderton
Abstract
Inherited mutations in BRCA1 seem to specifically increase the risk of developing basal-like breast cancers; so, Proia and colleagues investigated how BRCA1 might promote the formation of this subtype of breast cancer.Using samples from reduction mammoplasty (BRCA1+/+) and prophylactic mastectomy from individuals with BRCA1 mutations (BRCA1mut/+), Proia and colleagues transformed cell suspensions with four tumorigenic genes (TP53R175H, CCND1, PI3KCA and KRASG12V) that are
Hallmarks of cancer: the next generation. Weinberg, Hanahan. Cell 2011. PDF
Cell. 2011 Mar 4;144(5):646-74.
Los hallmarks del cáncer propuestos desde hace varios años por Weinberg incorporan ahora otras características ya propuestas por otros múltiples veces como la inflamación, la necrosis, las alteraciones metabólicas entre otras.
Cell. 2011 Mar 4;144(5):646-74.
Los hallmarks del cáncer propuestos desde hace varios años por Weinberg incorporan ahora otras características ya propuestas por otros múltiples veces como la inflamación, la necrosis, las alteraciones metabólicas entre otras.
Tuesday, March 08, 2011
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