Breast cancer: Luminal cells with an identity crisis

Breast cancer: Luminal cells with an identity crisis

Gemma K. Alderton

Abstract
Inherited mutations in BRCA1 seem to specifically increase the risk of developing basal-like breast cancers; so, Proia and colleagues investigated how BRCA1 might promote the formation of this subtype of breast cancer.Using samples from reduction mammoplasty (BRCA1+/+) and prophylactic mastectomy from individuals with BRCA1 mutations (BRCA1mut/+), Proia and colleagues transformed cell suspensions with four tumorigenic genes (TP53R175H, CCND1, PI3KCA and KRASG12V) that are