Otro de esos efectos alternos de NFkB

En este caso, al ser secuestrado en el nucleolo, ya no puede activar transcripcion (o inhibirla, como en el post pasado), promoviendo la apoptosis.

clipped from www.google.com The proapoptotic effects of sulindac, sulindac sulfone and indomethacin are mediated by nucleolar translocation of the RelA(p65) subunit of NF-κB from Oncogene by L A Stark The proapoptotic effects of sulindac, sulindac sulfone and indomethacin are mediated by nucleolar translocation of the RelA(p65) subunit of NF-κB Oncogene advance online publication, December 3, 2007. doi:10.1038/sj.onc.1210891 Authors: C J Loveridge, A D H MacDonald, H C Thoms, M G Dunlop & L A Stark