clasificacion de cientificos

http://bitesizebio.com/2007/12/11/a-classification-system-for-scientists/

Caspasas

En la revista Cell Death and Differentiation, se publicó una revisión especial para caspasas (Volume 14, Issue 1).
This review series includes comprehensive articles by experts in the caspase field, and covers the basic biology of caspases, their mechanisms of activation, cellular substrates, natural and synthetic inhibitors, apoptopic and non-apoptopic functions and role in inflammation and immunity.

Otro de esos efectos alternos de NFkB

En este caso, al ser secuestrado en el nucleolo, ya no puede activar transcripcion (o inhibirla, como en el post pasado), promoviendo la apoptosis.

clipped from www.google.com The proapoptotic effects of sulindac, sulindac sulfone and indomethacin are mediated by nucleolar translocation of the RelA(p65) subunit of NF-κB from Oncogene by L A Stark The proapoptotic effects of sulindac, sulindac sulfone and indomethacin are mediated by nucleolar translocation of the RelA(p65) subunit of NF-κB Oncogene advance online publication, December 3, 2007. doi:10.1038/sj.onc.1210891 Authors: C J Loveridge, A D H MacDonald, H C Thoms, M G Dunlop & L A Stark

Un bonito ejemplo del efecto antiapoptotico de NFkB

En este caso, en vez de activar la transcripcion de genes antiapoptoticos, inhibe la de un gen proapoptotico

clipped from www.google.com RelA/NF-κB recruitment on the bax gene promoter antagonizes p73-dependent apoptosis in costimulated T cells from Cell Death and Differentiation by L Tuosto RelA/NF-κB recruitment on the bax gene promoter antagonizes p73-dependent apoptosis in costimulated T cells Cell Death and Differentiation advance online publication, November 23, 2007. doi:10.1038/sj.cdd.4402264 Authors: R Cianfrocca, M Muscolini, V Marzano, A Annibaldi, B Marinari, M Levrero, A Costanzo & L Tuosto

Nuevo participante en la jugada, che!

Este articulo nos habla de un nuevo participante en la respuesta apoptotica al daño al ADN, como en la quimioterapia, funcionando rio arriba de la expresion de las IAPs, que a su vez son reguladas por NFkB. Esto nos provee de nuevas preguntas en nuestro tema

Che-1 activates XIAP expression in response to DNA damage Cell Death and Differentiation advance online publication 30 November 2007; doi: 10.1038/sj.cdd.4402284

X-linked inhibitor of apoptosis protein (XIAP) is a member of the inhibitor of apoptosis proteins family that selectively binds and inhibits caspase-3, -7 and -9. As such, XIAP is an extremely potent suppressor of apoptosis and an attractive target for cancer treatment. Che-1 is an antiapoptotic agent involved in the control of gene transcription and cell proliferation. Recently, we showed that the checkpoint kinases ATM/ATR and checkpoint kinase 2 physically and functionally interact with Che-1 and promote its phosphorylation and accumulation in response to DNA damage. These Che-1 modifications induce transcription of p53, and Che-1 depletion strongly sensitizes tumor cells to anticancer drugs. Here we show that Che-1 activates XIAP expression in response to DNA damage. This effect is mediated by Che-1 phosphorylation and requires NF-B. Notably, we found that XIAP expression is necessary for antiapoptotic activity of Che-1 and that in vivo downregulation of Che-1 by small interference RNA strongly enhanced the cytotoxicity of anticancer drugs.

Un panorama de la genomica en mexico

Es bueno enterarse de lo que se ha hecho y lo que se esta haciendo en Mexico. Echenle un vistazo.

clipped from compbiol.plosjournals.org Development of Genomic Sciences in Mexico: A Good Start and a Long Way to Go Rafael Palacios*, Julio Collado-Vides Citation: Palacios R, Collado-Vides J (2007) Development of Genomic Sciences in Mexico: A Good Start and a Long Way to Go. PLoS Comput Biol 3(9): e143 doi:10.1371/journal.pcbi.0030143

Regulacion de Smac por AMPc

Un articulo interesante en el que comprueban nuestros resultados previos, lo que es importante para asegurar la fiabilidad de la ciencia que hacemos . El AMP ciclico regula smac para inducir apoptosis.

clipped from www.ncbi.nlm.nih.gov Gene expression signatures of cAMP/PKA-promoted, mitochondrial-dependent apoptosis: Comparative analysis of wild-type and cAMP-deathless S49 lymphoma cells. 1: J Biol Chem. 2007 Nov 29 [Epub ahead of print]