Correciones y nuevos blancos...

The most important issue when trying to find mutations that cause disease via DNA sequencing is to keep the sequencing error rate as low as possible.

Whole-genome sequencing of DNA from two children with Mendelian disorders and from their healthy parents allows efficient correction of sequencing errors and the identification of causal genes.

Nature Methods 7, 350 (2010)
doi:10.1038/nmeth0510-350

http://www.nature.com/nmeth/journal/v7/n5/full/nmeth0510-350.html